Exploring the Early Endometrial-Blastocyst Interactome in Endometriosis: An Integrative Study.

ABSTRACT: Background: Background: Endometriosis affects 10% of women of reproductive age. Despite the well-known association between endometriosis and infertility, the mechanisms underlying this association remain to be elucidated. Methods: Implantation and pregnancy success rates were evaluated by a retrospective study of patients that underwent IVF using euploid embryos comparing healthy vs. endometriosis patients. To study the early embryo-endometrial dialogue, an interactome network was constructed using public RNAseq data from normal secretory-phase endometrial samples and day-5 blastocyst. Public bulk and single-cell RNAseq data from endometrial samples of endometriosis patients were used to detect alterations in the interactome. Results: Endometriosis patients required si

SUBMITTER: Schafir A 

PROVIDER: S-EPMC12649848 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature