Total Flavonoids of <i>Rhizoma drynariae</i> Enhance Bone Marrow Mesenchymal Stem Cell-Mediated Tendon-Bone Healing by Promoting Tissue Regeneration, Angiogenesis, and Modulation of Cytokine Expression.

ABSTRACT: (1) Objective: This study aimed to investigate the synergistic effect and underlying mechanisms of Total Flavonoids of Rhizoma drynariae (TFRD) in combination with Bone Marrow Mesenchymal Stem Cells (BMSCs) in the repair of tendon-bone injuries. (2) Methods: The effects of TFRD on the proliferation and migration of BMSCs were assessed using CCK-8 and scratch assays, and its potential to promote osteogenic and chondrogenic differentiation was evaluated. Concurrently, the pro-angiogenic effect of TFRD on Human Umbilical Vein Endothelial Cells (HUVECs) was observed. In vivo, a rat model of Achilles tendon-bone injury was established and animals were divided into four groups: SHAM, Model, BMSCs, and BMSCs + TFRD. After an 8-week intervention, the level of functional recovery was evaluat

SUBMITTER: Yang G 

PROVIDER: S-EPMC12649899 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature