Immunomodulation and Mechanical Characterization of Manuka Honey-Incorporated Near-Field Electrospun Bioresorbable Vascular Grafts.

ABSTRACT: (1) Current synthetic small-diameter vascular grafts fail frequently due to anastomotic hyperplasia and thrombosis caused by mechanical mismatch and incomplete reendothelialization. Polydioxanone near-field electrospun (NFES) vascular templates feature programmable pore sizes to facilitate transmural ingrowth of endothelial cells and show promise in reducing mechanical mismatch, but their potential as drug delivery systems remains unexplored. It was hypothesized that Manuka honey incorporation in NFES templates could reduce neutrophil extracellular trap (NET) release but decrease mechanical strength. (2) Templates were fabricated using 90 mg/mL polydioxanone in 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) and Manuka honey concentrations of 0%, 0.1%, 1%, and 10% v/v. Wall thickness

SUBMITTER: Snyder AE 

PROVIDER: S-EPMC12649915 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature