Multi-Omics Analysis Reveals Biaxial Regulatory Mechanisms of Cardiac Adaptation by Specialized Racing Training in Yili Horses.

ABSTRACT: Yili horses undergo coordinated physiological adaptations across systems in response to customized training. This study aimed to clarify the molecular mechanisms of these adaptations by integrating analyses of cardiac function and multi-omics (lipidomics, transcriptomics, miRNomics). We collected whole blood samples from ten Yili horses before and after 12 weeks of specialized racing training to perform these analyses. Results showed training induced adaptive cardiac remodeling, with substantial increases in LVIDd and LVIDs. At the molecular level, this was accompanied by extensive blood lipid reprogramming (383 differential lipids), enriched in energy pathways like fatty acid metabolism. Transcriptomic analysis identified 851 differential genes, also enriched in energy-related pathways (e

SUBMITTER: Wang T 

PROVIDER: S-EPMC12649962 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature