Multiscale Coronary Arterial Network Generation and Hemodynamics Using Patient-Specific Fractional Myocardial Blood Volume.

ABSTRACT: Ischemic heart disease (IHD) is the leading cause of death worldwide. Although 90% of the intramyocardial blood volume resides in the microvasculature, clinical imaging methods cannot visualize the microvascular coronary network in vivo, and non-invasive hemodynamic estimates overlook patient-specific microcirculatory contributions. Herein, we present a multiscale framework to extend the epicardial coronary tree and generate 1D microvascular networks in the myocardium based on ferumoxytol-enhanced magnetic resonance coronary imaging and fractional myocardial blood volume (fMBV) maps. Synthetic arterial networks were constructed from MRI data belonging to three swine, four healthy volunteers, and one IHD patient using a modified multistage, adaptive constrained constructive optimization app

SUBMITTER: Mahmoudi M 

PROVIDER: S-EPMC12649997 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature