Design Optimization and Mechanical Performance Evaluation of a Modified Coronary IV-OCT Catheter Adapted for Intracranial Navigation: A Preclinical Study.

ABSTRACT: The application of intravascular optical coherence tomography (IV-OCT) in neurovascular interventions is constrained by the mechanical inadequacy of conventional catheters in navigating the complex intracranial vasculature. To address this, we modified a coronary IV-OCT catheter, enhancing its mechanical performance for neurovascular applications. The modified catheter featured a 300 mm over-the-microwire segment and a dual-structured shaft (distal 50 mm nonbraided, proximal 250 mm braided) to improve trackability and pushability. We compared the modified and conventional catheters using a benchtop model with a simulated vessel path and an in vivo swine model. Trackability and pushability were quantitatively measured using resistance (N) and advancement distance (mm) in the simulated path.

SUBMITTER: Nairuz T 

PROVIDER: S-EPMC12650042 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature