Transcriptomics and Metabolomics Reveal Mechanisms Underlying the Adaptation of <i>Lamiophlomis rotata</i> to High Altitudes.

ABSTRACT: Lamiophlomis rotata (Benth.) Kudo is a typical alpine medicinal plant. However, the mechanism underlying its adaptation to high altitudes remains incompletely understood. In this study, we integrated transcriptome and metabolome analyses. Specifically, we used third-generation sequencing for building a reference transcriptome and second-generation sequencing for differential gene expression analysis. Our findings revealed that the activation of the hydrogen sulfide signaling pathway and the reprogramming of amino acid metabolism are probable adaptation mechanisms. Different from previous reports, the hydrogen sulfide signaling may regulate the activity of cellulose synthase in addition to enhancement of antioxidant capacity and accumulation of osmolytes. By altering the agronomic tr

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12650051 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature