Behavioral Variant Frontotemporal Dementia in the Context of Progressive Apraxia of Speech: A Clinico-Neuroimaging Case-Control Study.

ABSTRACT: Objective: Progressive apraxia of speech (PAOS) is a neurodegenerative syndrome characterized by impaired motor speech planning and programming, whereas behavioral variant frontotemporal dementia (bvFTD) is characterized by deviant behavioral (e.g., personality and social) features. Clinical and anatomic characteristics of bvFTD in the context of PAOS are understudied. Methods: We identified 12 participants with PAOS and features that were consistent with bvFTD at baseline or follow-up. Eleven completed a head MRI scan. We compared clinical features and anatomical patterns of atrophy in these 11 PAOS-bvFTD participants to 11 matched PAOS participants without bvFTD and 22 age- and sex-matched healthy controls. Statistical Parametric Mapping (SPM) was applied to visualize gray

SUBMITTER: Hossain N 

PROVIDER: S-EPMC12650068 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature