Cytokine Dynamics During Ustekinumab Induction as Predictors of Treatment Response in Crohn's Disease: An Observational Study.

ABSTRACT: Background/Objectives: Crohn's disease (CD) is a chronic immune-mediated disorder with heterogeneous response to biologic therapies. Ustekinumab (UST), an anti-IL-12/23 monoclonal antibody, is effective in CD, but predictive biomarkers of treatment response remain lacking. This study aimed to investigate cytokine dynamics during UST induction and to evaluate their association with clinical and biochemical outcomes in an observational cohort of CD patients. Methods: We prospectively recruited 31 adult patients with moderate-to-severe active CD initiating UST therapy at a tertiary referral center. Peripheral blood and stool samples were collected at baseline and weeks 4, 8, and 16. UST trough concentrations, C-reactive protein (CRP), fecal calprotectin (FC), hemoglobin, albumin

SUBMITTER: Minguez A 

PROVIDER: S-EPMC12650091 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature