Candida albicans Enhances Protease Activity and Activates MyD88-Dependent IL-1β Production in Human Keratinocytes.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common chronic skin disorder characterised by a highly inflamed local environment and elevated epidermal proteolytic activity. Changes in the skin mycobiome have been observed in this disease, specifically Candida albicans colonization positively correlating with AD severity, yet the mechanisms by which this fungus contributes to disease features remain elusive.

Objectives

This study aimed to elucidate how C. albicans can influence AD pathogenesis through its influence on keratinocyte (KC) proteolytic activity, inflammatory cytokine secretion and epidermal barrier integrity, as well as define the signaling pathways mediating these effects.

Methods

Immortalized human KC were co-cultured with C. albicans and changes in KC protease

SUBMITTER: Wang J 

PROVIDER: S-EPMC12650128 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature