L-Dopa Comparably Improves Gait and Limb Movements in Parkinson's Disease: A Wearable Sensor Analysis.

ABSTRACT: Background/Objectives: Spatio-temporal gait parameters have been proposed as surrogate markers for objective, remote monitoring of global motor status in Parkinson's disease (PD). Our observational, cross-sectional pilot study tested whether gait metrics, derived from wearable sensors, reflect dopaminergic responsiveness in both axial and appendicular functions. Methods: Twenty-two PD patients were evaluated both under and not under L-Dopa (ON and OFF states, respectively). Motor performance was assessed using wearable inertial sensors during standardized tasks involving gait and upper/lower limb movements. From the recorded kinematics, measures of movement amplitude, speed, rhythm, and consistency were extracted, and dopaminergic response was compared in appendicular and axi

SUBMITTER: Zampogna A 

PROVIDER: S-EPMC12650135 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature