Drug-Metabolizing Gene Expression Identity: Comparison Across Liver Tissues and Model Cell Lines.

ABSTRACT: Background: Human cell lines underpin modern biomedical research, offering reproducibility, standardisation, and unrestricted access to biological material. Among the 1206 human lines documented in the Human Protein Atlas, in vitro systems overcome the ethical and technical constraints of primary tissues. The liver is an organ of intricate structure, diverse physiological roles, and limited in vitro viability. Liver-derived cell lines are increasingly used to address the growing burden of liver disease and to accelerate pharmaceutical development, yet their capacity to replicate native hepatic functions remains uncertain. The mutational profiles and expression patterns of hepatocyte-characteristic genes provide critical benchmarks for their suitability for pharmacology and toxicolog

SUBMITTER: Arzumanian VA 

PROVIDER: S-EPMC12650171 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature