Follicular Fluid Amino Acid Alterations in Endometriosis: Evidence for Oxidative Stress and Metabolic Dysregulation.

ABSTRACT: Background/Objectives: Endometriosis (EM) is a chronic gynecological condition associated with infertility, oxidative stress, and altered metabolic regulation. Follicular fluid (FF) reflects the microenvironment of the developing oocyte, and changes in its amino acid composition may affect reproductive outcomes. This study aimed to characterize alterations in the amino acid composition of the FF in EM and to identify potential reproductive outcomes. Methods: Targeted metabolomic analysis of 20 amino acids was performed on FF samples from 56 women undergoing in vitro fertilization (17 with endometriosis, 39 controls). Amino acid concentrations were quantified and compared between groups, adjusting for age and body mass index. Pathway, biomarker, and multivariate analyses were

SUBMITTER: Kurdi C 

PROVIDER: S-EPMC12650251 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature