Eco-friendly synthesis of novel pyrazole derivatives and their anticancer and CDK2 inhibitory activities.

ABSTRACT: A series of 1-(2-pyridinyl)-4-aryl-1H-pyrazole-3,5-diamine derivatives (2-12) were designed and synthesized using a one-pot multicomponent reaction via both microwave-assisted and conventional techniques. The structural properties of the new compounds were established using spectroscopic data. The new derivatives were biologically assessed as promising CDK2 enzyme inhibitors. Then, the target pyrazoles were screened against both HepG2 and MCF-7 malignant cell lines. Compounds 4, 7, and 10 revealed significant CDK2 inhibitory activities with comparable potencies (IC₅₀ = 0.75, 0.77 and 0.85 µM, respectively) to that of roscovitine (IC₅₀ = 0.99 µM). Additionally, compounds 5, 6, and 11 demonstrated the best inhibitory activities, which are twice the activit

SUBMITTER: Abubshait SA 

PROVIDER: S-EPMC12650307 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature