Screening and Validation of Functional Residues of the Antimicrobial Peptide <i>Pp</i>Rcys1.

ABSTRACT: The excessive use of conventional antibiotics in aquaculture has created significant challenges, making it essential to explore and develop effective alternatives. Antimicrobial peptides (AMPs) have gained attention as potential therapeutic agents owing to their wide-ranging antibacterial effects and their ability to address pathogens resistant to conventional drugs. PpRcys1 is an antimicrobial peptide that mainly targets bacterial cell membranes, exhibiting a minimum inhibitory concentration of 8-32 μM. Its antibacterial activity should be further optimized. Before such optimization, however, it is crucial to identify the key amino acid residues that determine its functional activity. In this study, molecular dynamics simulations indicated that arginine 40 (ARG40), lysine 55 (LYS55

SUBMITTER: Tao M 

PROVIDER: S-EPMC12650370 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature