SMAnalyst: A Web Server for Spatial Metabolomic Data Analysis and Annotation.

ABSTRACT: Spatial metabolomics is a rapidly advancing field offering powerful insights into metabolic heterogeneity in biological tissues. However, its widespread adoption is hindered by fragmented tools and the lack of comprehensive, open-source GUI software covering the full analytical workflow (quality control, preprocessing, identification, pattern, and differential analysis). To address this, we developed SMAnalyst, an open-source, integrated web-based platform. SMAnalyst consolidates core functionalities, including multi-dimensional data quality assessment (background consistency, intensity, missing values), a comprehensive metabolite annotation scoring system (mass accuracy, isotopic similarity, adduct evidence), and dual-dimension spatial pattern discovery (metabolite co-expression and pixel

SUBMITTER: Mei Z 

PROVIDER: S-EPMC12650421 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature