Over-Expression of TNFRSF12A Promotes Immune Suppression and Facilitates Angiogenesis in Triple-Negative Breast Cancer.

ABSTRACT: The urgent need for novel therapeutic strategies in triple-negative breast cancer (TNBC)-characterized by absent ER, PR, and HER2 expression-stems from its association with a paucity of effective treatments and an adverse prognosis. This study identifies TNFRSF12A as a key gene specifically overexpressed in TNBC versus other subtypes. Validation with clinical specimens confirmed its exclusive upregulation in TNBC tissues, correlating significantly with worse patient outcomes. Functional enrichment analysis (STRING/DAVID) indicated TNFRSF12A's primary involvement in pathways positively regulating cell migration, angiogenesis, and hypoxia response. Immune infiltration profiling (TIMER/TISCH2) revealed selective enrichment of TNFRSF12A in cancer-associated fibroblasts (CAFs). Its expression s

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12650428 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature