Racial Differences in the Molecular Genetic Biomarkers of Diffuse Large B-Cell Lymphoma.

ABSTRACT: Background/Objectives: Diffuse large B-cell lymphoma (DLBCL) exhibits pronounced racial disparities in incidence and outcomes, yet the molecular basis remains poorly understood. Here, we examined racial differences in gene rearrangements (MYC, BCL2, BCL6), fusions (IGH::MYC, IGH::BCL2), and their interactions among White, Black, Asian, and Other-race groups in patients with DLBCL to uncover genetic drivers of disparities. Methods: We analyzed 919 DLBCL cases (2006-2023) from Johns Hopkins Hospital using fluorescence in situ hybridization to detect gene abnormalities. We used logistic regression and proportional odds models, adjusted for age and sex, to evaluate racial differences in five gene abnormalities and 10 gene-gene inte

SUBMITTER: Gomes MD 

PROVIDER: S-EPMC12650435 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature