MLH1 Promoter Variant -93G>A and Breast Cancer Susceptibility: Evidence from Azerbaijan.

ABSTRACT: Background: Breast cancer (BC) is the most common malignancy among women, and genetic predisposition plays a critical role in its development. Among DNA mismatch repair (MMR) genes, MLH1 is essential for maintaining genomic stability, and promoter variants may influence its transcriptional regulation. Variants in MMR genes, including MLH1, have been implicated in cancer susceptibility; however, evidence regarding the promoter polymorphism -93G>A (rs1800734) and its association with BC remains limited and inconsistent across populations. Methods: We conducted a case-control study of 143 breast cancer patients and 161 cancer-free controls of Azerbaijani origin. Genotyping of MLH1 -93G>A was performed using PCR-RFLP and validated by next-generation sequencin

SUBMITTER: Karimova N 

PROVIDER: S-EPMC12650484 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature