Triploid Cyprinid Fish (TCF) Under <i>Aeromonas</i> sp. AS1-4 Infection: Metabolite Characteristics and In Vitro Assessment of Probiotic Potentials of Intestinal <i>Enterobacter</i> Strains.

ABSTRACT: The majority of Aeromonas strains are opportunistic pathogens for both humans and animals, causing a variety of diseases and posing a considerable risk to their health. In the current study, triploid cyprinid fish (TCF) were infected with a novel pathogenic Aeromonas sp. AS1-4 for pathological analysis. TCFs receiving Aeromonas sp. AS1-4 challenge exhibited oxidative damage in the liver and spleen, along with significant changes in immune-related gene expressions. Metabolomics assay indicated that strain AS1-4 challenge may exhibit a significant impact on metabolic processes of amino acids, with methylsuccinic acid (MSA) identified as vital biomarker. Following that, three potential probiotics designated Enterobacter strains fkY27-2, fkY84-1 and fkY84-4 were iso

SUBMITTER: Kuang XY 

PROVIDER: S-EPMC12650594 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature