Peripheral Blood TCR Clonotype Diversity as a Biomarker for Colorectal Cancer.

ABSTRACT: There exists an urgent need to improve colorectal cancer (CRC) diagnosis due to limitations in current diagnostic approaches. Systematic characterization of the human T cell receptor (TCR) repertoire, coupled with advanced computational methods, provides a promising opportunity to develop more accurate and less invasive diagnostic strategies for this major malignancy. The main objective of this work is to establish a TCR repertoire-based diagnostic model for CRC using machine learning algorithms and to identify the most significant features contributing to accurate diagnosis. Through comprehensive comparative analysis of several machine learning algorithms, our results demonstrated that the Transformer model exhibited superior performance capabilities. The trained model achieved an area un

SUBMITTER: Zhu G 

PROVIDER: S-EPMC12650616 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature