Sex Differences in Individuals at High Risk of Atrial Fibrillation: A Primary Care Community Cohort Study, 2015-2024.

ABSTRACT: Background: Sex differences in epidemiology and outcomes in atrial fibrillation (AF) are well documented, but their role in early detection and risk stratification in primary care remains unclear. Methods: This study used an observational, retrospective cohort design, including 9677 individuals identified as being at high risk (Quartile 4 of a validated prediction model) for developing atrial fibrillation, aged 65-95 years, and without prior AF or stroke in the Terres de l'Ebre health region (Catalonia, Spain). Incident AF and comorbidities prevalence were assessed from 1 January 2015 to 31 December 2024. Analyses compared sex-specific differences. Results: During follow-up, 3370 individuals (8.4%) developed AF, with higher incidence in men than women (9.9% vs. 7.0%, <

SUBMITTER: Clua-Espuny JL 

PROVIDER: S-EPMC12650675 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature