Bidirectional Mendelian Randomization Analysis of the Causal Relationship Between Uterine Fibroids and Breast Cancer in East Asian Women.

ABSTRACT: Background/Objectives: This study was designed to investigate the potential causal relationship between uterine fibroids (UF) and breast cancer (BC) using genetic data in East Asian populations. Methods: We conducted a bidirectional two-sample Mendelian randomization (MR) analysis of UF and BC, selecting exposure-associated single-nucleotide polymorphisms (SNPs) from Biobank Japan and extracting outcome associations from the China Kadoorie Biobank for both directions. The primary estimator was inverse-variance-weighted (IVW), with robustness assessed using the weighted median, MR-Egger regression, and the MR-pleiotropy residual sum and outlier (MR-PRESSO). Results: The SNPs with (p < 5.0 × 10^-8) were selected as instrumental variables for UF (n

SUBMITTER: Lee Y 

PROVIDER: S-EPMC12650747 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature