Magnetic drug-loaded microbubbles for treating lower limb venous thrombosis under controllable rotating magnetic field.

ABSTRACT:

Objective

This study aimed to develop a poly (lactic-co-glycolic acid) (PLGA)-based magnetic loaded iron oxide (Fe₃O₄) and single-chain urokinase-type plasminogen activator (proUK) for enhancing thrombolysis under a controlled rotating magnetic field, specifically targeting acute lower limb venous thrombosis.

Background

Acute thrombotic disorders are significant health threats, however, the exploration of magnetic actuation as a treatment for acute thrombosis has been limited.

Methods

Magnetic microbubbles were prepared using a double emulsion method, loaded with Fe₃O₄ nanoparticles and proUK. The microbubble characteristics were analyzed through chemical, physical, and biological related technologies.

Results

Fe

SUBMITTER: Huang YM 

PROVIDER: S-EPMC12650771 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature