Epstein-Barr virus LMP1 promotes tumorigenesis in a murine epithelial tumor model.

ABSTRACT: Epstein-Barr virus (EBV), an oncogenic herpesvirus, is associated with diverse epithelial and lymphatic malignancies. The latent membrane protein 1 (LMP1) is well-established as a key oncogenic driver in B-cell malignancies, while its functional role in epithelial tumors remains poorly understood. This study aimed to establish an epithelial tumor model stably expressing LMP1 and investigate its oncogenic functions and mechanisms. We generated mouse lung epithelial cells TC-1 stably expressing EBV LMP1 using the PiggyBac transposon system (TC-1-LMP1). The TC-1-LMP1 model demonstrated that LMP1 enhanced proliferative and invasive capacities while reducing cell adhesion in vitro, and promotes aggressive tumor growth in vivo. RNA-seq analysis revealed that LMP1 increased the expr

SUBMITTER: Tan J 

PROVIDER: S-EPMC12650785 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature