Comprehensive analysis on the implications of IAH1 in cancer development and progression.

ABSTRACT:

Objective

This study aimed to elucidate the role of the IAH1 gene across multiple cancer types.

Methods

Using multi-omics data from public databases including TCGA, GTEx, TIMER, and cBioPortal, we analyzed the expression patterns of IAH1 and their correlations with prognostic outcomes, immune cell infiltration, immune checkpoint markers, tumor mutational burden (TMB), microsatellite instability (MSI), response to immunotherapy, and drug sensitivity through bioinformatic tools and R software.

Results

IAH1 expression was significantly upregulated in most cancers and associated with adverse prognosis. Elevated IAH1 levels correlated strongly with immune-related gene expression, immune checkpoint levels, TMB, MSI, and immune infiltration. Moreover, IAH1 expression was lin

SUBMITTER: Sun C 

PROVIDER: S-EPMC12650796 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature