Mathematical Modeling of Cell Death and Survival: Toward an Integrated Computational Framework for Multi-Decision Regulatory Dynamics.

ABSTRACT: Mathematical modeling is essential for understanding the complex regulatory pathways governing cell death and survival, including apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, and immunogenic cell death (ICD)-a functional category comprising diverse morphological types capable of activating immune responses. The growing number of models describing individual signaling pathways poses the challenge of integrating them into a cohesive framework. This review aims to identify common components across existing ordinary differential equation models that could serve as key nodes to merge distinct signaling modalities. Proposed models highlight Bcl-2, Bax, Ca², and p53 as shared regulators linking autophagy and apoptosis. Necroptosis and apoptosis are interconnected via TNF

SUBMITTER: Kutumova E 

PROVIDER: S-EPMC12651094 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature