Wireless Acousto-Piezoelectric Conduit with Aligned Nanofibers for Neural Regeneration.

ABSTRACT: Peripheral nerve injury (PNI) represents a significant clinical challenge, leading to severe motor and sensory dysfunction, as well as irreversible tissue atrophy. Autograft has been commonly utilized as the clinical gold standard; however, it is limited by donor availability and secondary surgery requirements. Here, an ultrasound-responsive, highly aligned piezoelectric nanofiber nerve guidance conduit (APNF-NGC) is introduced for peripheral nerve regeneration. Fabricated from electrospun poly-l-lactic acid (PLLA) nanofibers, the APNF-NGC features an anisotropically oriented architecture with shear piezoelectricity, providing both structural support and wireless electrical stimulation. The incorporation of polyethylene glycol (PEG) tailors mechanical properties, increases piezoelectric-ph

SUBMITTER: Jeon S 

PROVIDER: S-EPMC12651110 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature