Sestrin2 Exerts a Novel Protective Effect Against LPS-Induced Ferroptosis via the Nrf2-SLC7A11-GPX4 Signaling Axis.

ABSTRACT: Uveitis is a leading cause of visual impairment linked to systemic inflammatory diseases. Current corticosteroid treatments are limited by significant long-term side effects. Sestrin 2 (SESN2), a stress-responsive antioxidant protein, is implicated in the regulation of ferroptosis and inflammation. This study investigates SESN2's role in modulating inflammation and ferroptosis in endotoxin-induced uveitis (EIU) models, aiming to develop safer therapeutic alternatives for uveitis management. C57BL/6 mice were subjected to EIU via intravitreal injection of lipopolysaccharide (LPS) with or without SESN2-overexpressing adeno-associated virus (AAV). Clinical evaluations, cytokine profiling, and ferroptosis marker assessments were conducted. Additionally, BV2 microglial cells were genetically mo

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12651112 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature