Comparative Evaluation of [⁶⁸Ga]Ga-Fibroblast Activation Protein Inhibitor vs. [¹⁸F]FDG as a Novel Radiotracer for Biology-Guided Image Radiotherapy.

ABSTRACT: Background/Objectives: Biology-guided radiotherapy (BgRT) is a novel technology utilizing PET radiotracer emissions to deliver image-guided adaptive RT. 18F-Fluorodeoxyglucose ([¹⁸F]FDG) is the most common PET radiotracer but has background in the liver and brain because it is taken up by viable tumor cells as well as inflammatory cells. Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts with minimal expression in normal tissues. FAP inhibitors (FAPIs) bind to FAP, and a FAPI labeled with Gallium-68 (68Ga) is a novel radiotracer with high tumor selectivity. Multiple studies have compared [⁶⁸Ga]Ga-FAPI-04 vs. [¹⁸F]FDG for diagnostic imaging, but [⁶⁸Ga]Ga-FAPI-04 vs. [¹⁸F]FDG have never been comp

SUBMITTER: Qiu L 

PROVIDER: S-EPMC12651341 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature