Blood Melatonin in Breast Milk-Fed Preterm Infants: Longitudinal Biomonitoring to 38 Weeks' Postmenstrual Age (ProMote Study).

ABSTRACT: Background/Objectives: Melatonin, produced by the placenta and pineal gland, regulates circadian timing and has antioxidant and immunomodulatory actions. After birth, neonatal secretion is low and its circadian pattern matures over months; evidence in preterm neonates is mixed. We longitudinally monitored morning blood melatonin from birth to 38 weeks' postmenstrual age (PMA) in breast milk-fed preterm neonates, assessing differences by time of birth (day vs. night), PMA, and weight-for-gestational-age (WfGA). Methods: A prospective NICU cohort, conducted within the ProMote study. In total, 132 preterm neonates were recruited from 112 mothers. For infants ≥33 weeks' GA, three samples were obtained: umbilical cord (available in 94; otherwise at the first NICU admission), day o

SUBMITTER: Kokkinaki T 

PROVIDER: S-EPMC12651348 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature