Blood-brain barrier opening as a predictor of epilepsy and mortality after subarachnoid haemorrhage.

ABSTRACT:

Background

We determined the predictive power of semi-automated blood-brain barrier assessment and other variables collected during neurocritical care for the outcome of 'epilepsy or late death' following aneurysmal subarachnoid haemorrhage.

Methods

This is a secondary analysis of the prospective, non-interventional, prognostic DISCHARGE-1-cohort from six university hospitals in Germany. All patients who underwent at least one contrast-enhanced MRI during neurocritical care were included. Initial clinical scores and Modified Rankin Scale at day 14 were available. Subdural electrocorticography was scored for seizures and spreading depolarisations. Two MRIs, one post-aneurysm occlusion and another post-neuromonitoring, were semi-automatically segmented into cerebrospinal fluid

SUBMITTER: Dreier JP 

PROVIDER: S-EPMC12651435 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature