Novel CTC Detection Method in Patients with Pancreatic Cancer Using High-Resolution Image Scanning.

ABSTRACT:

Background/objectives

Appropriate biomarkers are necessary for early diagnosis and multidisciplinary treatment of pancreatic ductal adenocarcinoma (PDAC). In recent years, the clinical utility of circulating tumor cells (CTC) as biomarkers for various can-cers has been reported; however, their detection rate in PDAC remains low, and clinical evidence is not yet established. CTC detection methods with high reliability and per-formance are essential for clarifying the importance of CTC in patients with PDAC.

Methods

A total of 5 mL peripheral blood samples were collected from 38 patients newly diagnosed with PDAC and 17 healthy controls. Negatively enriched cells were immunofluorescently stained with EpCAM-phycoerythrin and cell surface vi-mentin-fluorescein isothiocyanate (CS

SUBMITTER: Manabe T 

PROVIDER: S-EPMC12651565 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature