CBD Disrupts Malme-3M Cell Metabolism via Glycolytic Shift and Redox Imbalance.

ABSTRACT:

Background

Accumulating evidence suggests that cannabidiol (CBD) exerts variable effects on cancer cells that influence cellular activity, including growth. While anecdotal evidence abounds, mechanistic studies have lagged.

Methods

Malme-3M cells derived from melanoma and less-aggressive BJ fibroblast cells were incubated with CBD. CE-MS mass spectroscopy was used to measure metabolite changes resulting from CBD treatment.

Results

Data indicate a differential response between malignant Malme-3M cells and BJ fibroblasts with respect to metabolites critical for primary metabolic function. A significant reduction in TCA metabolites is seen with a corresponding increase in glycolytic output in the Malme-3M cell line. A similar reduction in TCA activity in BJ fibroblasts a

SUBMITTER: Shelton LM 

PROVIDER: S-EPMC12651666 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature