Progress in Research on the Mechanism of GABA in Improving Sleep.

ABSTRACT: Sleep disorders represent a growing global health concern with significant socio-economic impacts. GABA, a natural bioactive compound abundant in various fermented foods, especially probiotic-fermented foods, has garnered increasing attention for its potential to improve sleep quality. This review systematically elucidates the multi-pathway mechanisms by which GABA regulates sleep, focusing on (1) indirect modulation of central sleep-wake circuits via the gut-brain axis through vagal nerve, neuroendocrine, and immune pathways; (2) potential entry into the brain by leveraging the dynamic permeability of the blood-brain barrier (BBB) and transporter-mediated active transport; and (3) metabolic conversion into active substances like γ-hydroxybutyrate (GHB), which synergistically optimizes sle

SUBMITTER: Li S 

PROVIDER: S-EPMC12651798 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature