Development and Validation of a Site-Specific Tumor Burden Score for Predicting Surgical Outcomes in Advanced Ovarian Cancer.

ABSTRACT: Objective: The relationship between surgical outcomes and metastatic sites in ovarian cancer (OC) is known, but the role of metastatic site-specific tumor burden remains unclear. Methods: We prospectively analyzed data from 202 OC patients. We developed a preoperative protocol evaluating tumor burden in 30 metastatic sites and created a predictive score for suboptimal cytoreduction, which was externally validated. Results: MRI-assessed tumor burdens demonstrated superior consistency with surgical findings compared to CT (κ = 0.4-1.0). Three site-specific tumor burdens (diaphragmatic spleen surface, hepatorenal recess, mesentery), upper abdominal tumor burden, and two clinical factors were identified as predictors of suboptimal cytoreduction. The predictive score incorp

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12651799 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature