Ultrasonic complexation with Lycium barbarum polysaccharide significantly enhances the aqueous solubility and bioavailability of curcumin.

ABSTRACT: Curcumin is a natural bioactive compound with a wide range of established health benefits. However, its practical applications are severely limited due to extremely poor aqueous solubility, which directly leads to low bioavailability. While polysaccharides like Lycium barbarum polysaccharide (LBP) can partially improve curcumin solubility, their solubilization efficiency remains limited. To overcome this challenge, we implemented ultrasonication as an effective processing strategy to enhance LBP's capacity to promote curcumin dissolution. Our findings show that ultrasound-induced cavitation and related physico-chemical effects markedly improve LBP's solubilization performance. The ultrasonically-assisted curcumin-LBP complex (CL-U) was systematically optimized through response surface meth

SUBMITTER: Zhao LQ 

PROVIDER: S-EPMC12651804 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature