Lipid, Metabolomic and Gut Microbiome Profiles in Long-Term-Hospitalized Cardiac Patients-An Observational and Retrospective Study.

ABSTRACT: Background/Objectives: Long-term hospitalization in cardiac patients is associated with significant metabolic and microbial alterations that may influence disease progression and prognosis. Although lipid imbalances, metabolomic shifts, and gut microbiome dysbiosis have each been linked individually to cardiovascular outcomes, their integrated evaluation in long-term-hospitalized patients remains underexplored. Methods: We conducted a retrospective observational study including 51 cardiac patients hospitalized for more than 25 days, compared with a control group of 41 patients hospitalized for short and intermediate durations (3-24 days). Clinical and demographic data were collected, alongside lipid profiling, metabolomic assessment through liquid chromatography-mass spectrom

SUBMITTER: Grigore I 

PROVIDER: S-EPMC12651827 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature