The B-S₂CALED Score's Utility in Predicting Stroke Risk in Breast Cancer Patients with Atrial Fibrillation.

ABSTRACT: Background: Breast cancer (BC) patients have heightened risks of atrial fibrillation (AF) and ischemic stroke (IS). Standard IS scores are poorly validated in cancer, omit cancer-specific factors, and guidelines offer no cancer-tailored management. Objectives: To develop and validate a novel score to predict IS risk in BC patients with AF. Methods: Data sources: UH Seidman Cancer Center (derivation; 40% set aside for internal validation) and MCG Cancer Center (external validation). Adults ≥ 18 years old with DCIS or stage I-IV BC who developed AF after diagnosis were included. Variable selection by LASSO Cox regression; continuous predictors dichotomized via cubic splines; points assigned from multivariable hazards to form B-S₂CALED. Continuous scores were s

SUBMITTER: Seth L 

PROVIDER: S-EPMC12651892 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature