Bioactive Flavonoids from <i>Paulownia tomentosa</i> Flowers: Extraction Optimization and α-Glucosidase Inhibitory Kinetics.

ABSTRACT: Paulownia tomentosa flowers are rich in flavonoids with promising biological activities. However, few studies have investigated their potential for α-glucosidase inhibition. This study compared ultrasound-assisted cellulase extraction and ultrasound-assisted aqueous two-phase extraction for the recovery of flavonoids from Paulownia tomentosa flowers. The aqueous two-phase extraction method demonstrated superior performance, with optimal conditions determined as 17.80% (NH₄)₂SO₄, 12 min ultrasonication, and 44 °C. Purification was efficiently achieved using NKA-9 macroporous resin. Scanning electron microscopy revealed that ultrasonic treatment disrupted the cell walls, facilitating flavonoid release. Ultra-performance liquid chromatography-tan

SUBMITTER: Jiang F 

PROVIDER: S-EPMC12652004 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature