Sub-15 nm Nanoparticles for Drug Delivery: Emerging Frontiers and Therapeutic Potential.

ABSTRACT: Nanoparticles (NPs) have significantly changed the field of drug delivery, offering control over pharmacokinetics, biodistribution, and targeted therapy. Among these, ultrasmall nanoparticles (USNPs) with sizes of approximately 5-15 nm have garnered significant interest due to their unique physicochemical properties, including enhanced cellular uptake, deeper tissue penetration, and prolonged systemic circulation. This review explores the fundamental principles governing sub-15 nm nanoparticles, their classification, and their distinctive advantages in pharmaceutical applications. Various types of nanoparticles, including polymeric, lipid-based, metallic, and carbon-based nanosystems, are examined in the context of drug delivery in cancer therapy. We detail how sub-15 nm polymeric nanopart

SUBMITTER: De T 

PROVIDER: S-EPMC12652079 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature