Synergistic and Intelligent Hydrogel for Conducting Osteoblast Proliferation: Synthesis, Characterization, and Multifunctional Properties.

ABSTRACT: Current trends in intelligent hydrogels design for tissue engineering demand multifunctional biomaterials that respond to external stimuli, while maintaining adhesion, controlled degradation, and cytocompatibility. The present work describes the synthesis and characterization of a novel, intelligent and synergistic hydrogel for promoting osteoblastic growth and regeneration. The hydrogel comprises a complex matrix blend of natural biodegradable polymers, vitamins (A, K2, D3, and E), and bioactive components such as zinc phosphate nanoparticles and manganese-doped hydroxyapatite to improve osteoblastic functionality. The hydrogel proved to have physicochemical properties for recovery and self-healing, highlighting its potential application as an auxiliary in bone rehabilitation. Key paramet

SUBMITTER: Guillen-Carvajal KM 

PROVIDER: S-EPMC12652084 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature