Response Surface Methodology Optimization of Electron-Beam-Irradiated Carboxymethyl Cellulose/Citric Acid-Based Hydrogels.

ABSTRACT: Electron beam irradiation (EBI) is an environmentally friendly cross-linking technique that can form covalent bonds between natural polymers without the use of chemical cross-linkers. In this study, carboxymethyl cellulose (CMC; 3000 cPs) and citric acid (CA) were used to prepare hydrogels under low-dose EBI conditions (7 kGy). The effects of composition variables were statistically analyzed using response surface methodology based on central composite design. The concentrations of CMC (4-14 wt%) and CA (1-4 wt%) were selected as independent variables, while the gel fraction, water absorption, and elastic modulus were employed as responses. Analysis of variance confirmed that the quadratic models were statistically significant (p < 0.05) with a high predictive reliability (R^2</

SUBMITTER: Choi SR 

PROVIDER: S-EPMC12652089 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature