Genomics and Multi-Omics Perspectives on the Pathogenesis of Cardiorenal Syndrome.

ABSTRACT:

Background

Cardiorenal syndrome (CRS) reflects bidirectional heart-kidney injury whose mechanisms extend far beyond hemodynamics. High-throughput genomics and multi-omics now illuminate the molecular circuits that couple cardiac and renal dysfunction.

Methods

We narratively synthesize animal and human studies leveraging transcriptomics, proteomics, peptidomics, metabolomics, and non-coding RNA profiling to map convergent pathways in CRS and to highlight biomarker and therapeutic implications.

Results

Across acute and chronic CRS models, omics consistently converge on extracellular matrix (ECM) remodeling and fibrosis (e.g., FN1, POSTN, collagens), immune-inflammatory activation (IL-6 axis, macrophage/complement signatures), renin-angiotensin-aldosterone system hyperac

SUBMITTER: Ang SP 

PROVIDER: S-EPMC12652397 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature