Dual-Crosslinked Gelatin/Dextran Medical Hydrogels Based on Aldimine Condensation and Photopolymerization.

ABSTRACT: Hydrogels have attracted considerable attention as biomedical materials owing to their distinctive properties; however, improvements in mechanical strength, biodegradability, and biocompatibility remain essential for advanced clinical applications. This study developed a new dual-crosslinked hydrogel based on gelatin (Gel) and dextran (Dex) via sequential aldimine condensation and photopolymerization. Natural Gel and Dex were functionalized to synthesize methacrylated Gel (GelMA) and oxidized Dex (ODex), respectively. An imine-linked network was initially formed between GelMA and ODex via aldimine condensation, followed by a second crosslinked network generated through blue-light-induced free-radical polymerization of GelMA, yielding dual-crosslinked hydrogels (GMODs). ¹H NMR an

SUBMITTER: Ding X 

PROVIDER: S-EPMC12652792 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature