Long Non-Coding RNAs in Multiple Sclerosis-Differential Expression and Functional Implications.

ABSTRACT:

Background/objectives

Long non-coding RNAs (lncRNAs) are increasingly recognized as key regulators of immune pathways and may hold diagnostic and therapeutic relevance in autoimmune diseases such as Multiple Sclerosis (MS). However, research on lncRNAs in MS remains fragmented and geographically clustered. This systematic review aimed to collate and critically evaluate studies of lncRNA expression in MS, assess consistency of findings across studies, and synthesize proposed functional implications of the most frequently studied lncRNAs.

Methods

This PROSPERO-registered review (CRD420250575938), conducted in accordance with PRISMA, searched PubMed, Scopus, Embase, and Web of Science (2010-2024) for studies evaluating lncRNA expression in adult MS (≥18 years of age). Eligible

SUBMITTER: Misra K 

PROVIDER: S-EPMC12652798 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature