Alginate-Aluminosilicate Clay Beads for Sustained Release of Chlortetracycline Hydrochloride: Development and In Vitro Studies.

ABSTRACT: This study reports the preparation of alginate (Alg) beads incorporating different amounts of halloysite nanotubes (HNTs) and kaolin (K) in the presence of Ca²⁺ ions to compare their drug loading and release behaviors. The resulting composites, HNTs@Alg and K@Alg, were characterized using FTIR, SEM-EDS, XRD, and XPS analyses. Chlortetracycline hydrochloride (CTC) was employed as a model antibiotic to evaluate their drug delivery performance. The concentration of Alg and the incorporation of HNTs or K markedly influenced the adsorption capacity and release profile. The maximum drug loading capacities were 48.12 ± 1.4 mg/g for HNTs, 40.1 ± 1.2 mg/g for K, 59.85 ± 2.3 mg/g for HNTs@Alg-1 (1 g HNTs and 1% Alg), and 68.74 ± 2.1 mg/g for K@Alg-1 (1 g K and 1% Alg). The inclusion of Al

SUBMITTER: Laouameria AN 

PROVIDER: S-EPMC12652813 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature