Probiotic Modulation in Aging: Strain-Specific Geroprotective Effects in <i>Caenorhabditis elegans</i>.

ABSTRACT: Elderly individuals are more vulnerable to disease due to their increased frailty. Emerging evidence highlights the potential of probiotics as geroprotective agents by maintaining gut health and modulating key physiological processes involved in aging, such as inflammation, cognitive functions, and metabolism. Here, we investigated the geroprotective potential of four probiotic strains (Lacticaseibacillus paracasei LPC1114, Limosilactobacillus reuteri PBS072, Bifidobacterium breve BB077, and Bifidobacterium animalis subsp. lactis BL050) using Caenorhabditis elegans as an aging model. Mid-life healthspan parameters were assessed, including lifespan, motility, ROS levels, lipofuscin accumulation, and cognitive capabilities. The probiotics exhibited s

SUBMITTER: Sciandrone B 

PROVIDER: S-EPMC12652852 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature