Novel Aurone Derivative Ameliorates MASH Lipid Metabolism via the AMPK-ACC-PPARα Axis.

ABSTRACT: Metabolic dysfunction-associated steatohepatitis (MASH), a progressive form of metabolic dysfunction-associated fatty liver disease (MASLD), is characterized by disrupted lipid metabolism and persistent inflammation, which can lead to cirrhosis and hepatocellular carcinoma. The novel pan-peroxisome proliferator-activated receptor (PPAR) agonist 1d has been previously shown to alleviate insulin resistance and hepatic steatosis in type 2 diabetic (T2DM) mice; however, its mechanism of action remains unclear. Our integrated in vitro and in vivo findings demonstrate that compound 1d significantly improves disordered hepatic lipid metabolism by modulating the AMPK-ACC-PPARα axis-specifically, by upregulating AMPK expression and phosphorylation, inhibiting ACC activity, downregulat

SUBMITTER: Bai S 

PROVIDER: S-EPMC12652917 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature