Instability in the Penta-C and Penta-D Loci in Microsatellite-Unstable Endometrial Cancer.

ABSTRACT: Endometrial cancer (EC) is the most common gynecologic cancer. Early detection is one of the most important predictors of survival. The cancer is curable if detected early but the five-year survival rate in advanced cases can be as low as 22%. Microsatellite instability (MSI) testing is used to screen populations for Lynch Syndrome (LS), the most common cause of inherited EC, and to classify EC into distinct groups with unique histological, prognostic, and molecular features. Accurate sample identification is crucial for successful MSI testing because instability is assessed by comparing amplification patterns in markers in the normal and tumor samples that must be taken from the same individual. Penta-C and Penta-D pentanucleotide markers are used widely for sample identification in not o

SUBMITTER: Yilmaz A 

PROVIDER: S-EPMC12652968 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature